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Lamotrigine was originally developed as an antiseizure drug because of its ability to reduce folate levels. At the time of the drug's development, it was thought that folate depletion would treat epileptic activity. Although this is now known to be incorrect, the drug did serendipitously treat seizures effectively. Currently, pharmacologists understand that Lamotrigine reduces neuronal activity via a variety of mechanisms. The most commonly accepted mechanisms of action are enhancement of sodium channel inactivation and possible inhibition of synaptic glutamate release. In early studies, patients with epilepsy who were taking Lamotrigine reported increases in a subjective sense of well-being, and this led to its exploration as a psychotropic drug. From a neuropsychiatric standpoint, Lamotrigine appears to inhibit uptake of serotonin, dopamine, and noradrenaline.

Other names for this medication:
Lamotrigine, Lamictal, Daksol, Epitec, Flamus, Labileno, Lafigin, Lamal, Lambipol, Lamez, Lamictin, Lamidus, Lamirax, Lamitor, Lamitrin, Lamogine, Lamolep, Lamotrigin, Lamotrigina, Lamotrix, Lomarin, Meganox,

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Lamotrigine is a medicine used to treat epilepsy.

It can also help prevent low mood (depression) in adults with bipolar disorder.

Lamotrigine is available on prescription. It comes as tablets that you can either chew or dissolve in water to make a drink.

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Potential dual metabolic activation of 6-EC involving the formation of bis-electrophiles, i.e., a mono-diol-epoxide and a mono-ortho-quinone within the same structure, bis-diol-epoxides, and bis-ortho-quinones was observed as well. Actually, poor quality imaging and geometrical assumptions are the main limitations of LVEF measured by echocardiography. Primary surgical treatment is a very effective modality against locally limited tonsillar carcinoma. Influence of vitreous factors after vitrectomy for macular edema in patients with central retinal vein occlusion. Current knowledge of MicroRNAs and noncoding RNAs in virus-infected cells.

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MMP11 vaccine induced cell mediated and antibody immune response and exerted significant antitumoral protection in mice with colon cancer in prophylactic and therapeutic settings. From May 2008 to April 2009, 62 pregnant women who underwent elective cesarean section in the Department of Obstetrics, Affiliated Hospital of Qingdao University Medical College, were recruited, including 32 with GDM (GDM group) and 30 with normal glucose tolerance test (control group). H-reflexes can be reliably used in longitudinal studies to investigate mechanisms of recovery post-SCI. A preliminary study on the therapeutic effects of a calcium antagonist (diltiazem) on primary congestive cardiomyopathy. A case-control study of dietary salt intake in pediatric-onset multiple sclerosis.

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These data demonstrate that tolerance develops to both the reinforcing and aversive properties of opioids and suggest that differential cross-tolerance may provide a useful method for determining the pharmacological basis underlying drug-induced motivational effects. Metabolic disorders of the brain are extensive and to encompass these disorders in two articles is impossible. Cyclosporine elimination in the presence of TOR inhibitors: effects on renal function, acute rejection, and safety. Quality of information was appraised independently by 2 health professionals, 1 young adult with JIA, and a parent using the DISCERN tool.

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