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Beclabuvir (Ribavirin)

Beclabuvir in combination with PEGASYS (peginterferon alfa-2a) is indicated for the treatment of patients 5 years of age and older with chronic hepatitis C (CHC) virus infection who have compensated liver disease and have not been previously treated with interferon alpha. Beclabuvir should be taken with food. Beclabuvir should be given in combination with PEGASYS; it is important to note that Beclabuvir should never be given as monotherapy. See PEGASYS Package Insert for all instructions regarding PEGASYS dosing and administration.

Other names for this medication:
Ribavirin, Rebetol, Copegus, Alfater, Beclabuvir, Boceprevir, Daclatasvir, Daklinza, Dasabuvir, Elbasvir, Filibuvir, Hepcinat, Hepcvir, Incivek, Kipferon, Ledifos, Ledipasvir, Miravirsen, Multiferon, Olysio, Ombitasvir, Paritaprevir, Pegasys, Pegetron, Pegintron, Rebetron, Resof, Setrobuvir, Simeprevir, Sofab, Sofovir, Sovaldi, Sylatron, Technivie, Telaprevir, Veldona, Victrelis, Zepatier,

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Beclabuvir is used in combination with injectable interferon alfa-2b, peginterferon alfa-2a, or peginterferon alfa-2b to treat chronic hepatitis C infection. The combination of Beclabuvir and peginterferon alfa-2b is used to treat adults and children 3 years of age and older who show symptoms of liver damage. Beclabuvir is an antiviral agent that treats hepatitis C virus.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet
  • Capsule

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Local infusion of prostaglandin E1 stimulates mandibular bone formation in vivo. Nineteen patients underwent endoscopic treatment for complications of hepatic hydatid disease. Lift velocities, the velocity components along the transverse direction, of the circular near-wall capsules decrease as they approach the centerline, while those of the elliptic and biconcave near-wall capsules do not show this trend, which might result from the short range of the simulation time. Visual acuity testing, biomicroscopic slit-lamp examination, and indirect ophthalmoscopy were performed on a 5-year-old boy with a progressively enlarging white lesion in the anterior chamber of the right eye.

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There were bilateral projections to the ventromedial (VM), parafascicular (PF), centromedian (CM) and paracentral (PC) nuclei and unilateral projections to the centrolateral (CL), mediodorsal (MD) and thalamic reticular nucleus (Rt). At each evaluation, LVEF and LV contraction synchrony were assessed during each pacing mode.

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We studied trophoblast cells isolated from selected placental tissue from 20 controls and 20 preterm patients after cesarean sections. The decrease in testicular high-affinity binding site for FSH correlated with the degree of hypospermatogenesis found in idiopathic male infertility, but, on the contrary, the hCG (LH) receptors showed no correlation with the degree of impairment of spermatogenesis.

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Assessment of performance improvement in content-based medical image retrieval schemes using fractal dimension. The effect of the extract on specific physiological functions, including insulin secretion, pancreatic beta-cell viability, GSK3 beta phosphorylation, lipolysis and glucose uptake was measured. Associations were not significantly different according to different strata of age, BMI, alcohol drinking, or second-hand tobacco smoke exposure status. Heart diseases, including myocardial infarction (MI) and congestive heart failure (CHF), have high mortality rates. Each element was characterized by its ability to confer estrogen responsiveness when cloned in either orientation next to a chimeric reporter gene consisting of the herpes simplex virus thymidine kinase promoter and the chloramphenicol acetyl transferase-coding region.

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Bone mineral density and fracture among prevalent kidney stone cases in the Third National Health and Nutrition Examination Survey. Bidirectional placental transfer of Bisphenol A and its main metabolite, Bisphenol A-Glucuronide, in the isolated perfused human placenta. Enhanced cardiovascular risk stratification based on biomarkers, symptoms and classical risk factors should be performed in patients with pre-existing diabetes mellitus. However, a grown H3 hemagglutinin-specific T cell line (L2), previously shown to be restricted by HLA-DR molecule (DR1) for interaction with antigen-presenting cells and devoid of allogeneic reactivity, exerts an HLA class II-restricted helper activity. Bronchiolitis is the most common respiratory disease in children under 2 years-old and a major cause of hospitalization in young children, especially during the winter.

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Participants completed a task in which they had to use feedback to learn to accurately estimate the duration of one second. megacephala compared to the native species, possibly reflecting a history of admixture. Dissociation rates of the inhibitor-kinase complexes were shown to be key parameters to differentiate both series.

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In addition to HT-2 toxin, 4-deacetylneosolaniol and T-2 tetraol, a trace amount of neosolaniol was transformed from T-2 toxin by rat intestinal strips. In the present study, the effect of PL on differentiation of rat bone marrow MSCs into cardiomyocytes was studied. The prognosis depends on the location and possible modes of treatment. To explore the relationship among oral lichen planus(OLP), depression and gonadal hormones in female patients with OLP.

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In various cancer cells exposed to a continuous glycolytic block, we identified a recurrent reprogramming mechanism involving sustained mTORC1 signaling that underlies escape from glycolytic addiction. Our studies also demonstrated that the mechanism of inhibition of NGcT during chronic enteritis was secondary to a reduction in the number of B(0)AT1 co-transporters in the villus cell BBM without a change in the affinity of the co-transporter. We found reduced bone mass in patients with type 1 DM at the time of the clinical diagnosis. The designation as congruent is important as incongruent joints generally are regarded as requiring a salvage-type procedure.

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At baseline, the risk factors are age, belief that work causes pain, and somatization tendency, and at follow-up, expectation of pain is the major risk factor. Data collection took place by gathering information from medical records and the analysis was performed using descriptive statistics.

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Among these are individualized: atrophic carcinoma, foamy gland, pseudohyperplastic, microcystic, certain subtypes of ductal adenocarcinoma and hormone-treated adenocarcinoma, which because of minimal architectural and/or cytological atypia are often under-diagnosed, especially in small tissue fragments. Clinical records of pediatric trauma patients admitted to a level 1 trauma centre between 1991 and 2009 were analyzed.

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The chaperone activity of trigger factor is distinct from its isomerase activity during co-expression with adenylate kinase in Escherichia coli. These results demonstrate that HY253, a novel antiproliferative compound isolated from the roots of Aralia continentalis, induces cell cycle arrest at the G(1) phase and apoptosis in A549 cells. The German life sciences program covers three disciplines: 1) medicine, 2) biology, and 3) biological processing.

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Peripheral chemical sympathectomy by means of 6-hydroxydopamine does not influence the calorigenic effects of dobutamine, when given 3 days after 6-hydroxydopamine administration. This fall-rise-fall pattern was consistent for cholesterol in 17 of 28 women studied and these women were heavier (P0.05), had a greater mean Quetelet Index (P0.05), and had been using OCs for a shorter mean period of time (P0.05). The PTEN-negative cell line displayed greater sensitivity to the growth inhibitory effects of the PI3K inhibitor, LY294002 and rapamycin, an inhibitor of the PI3K/Akt downstream mediator mTOR, compared with the PTEN-positive cell lines.

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Evidence that electronic health records can promote physician counseling for healthy behaviors. According to the rapidly increasing research in this field, both in academia and industry, a breakthrough appears likely, once stability problems (nanoparticles) and safety concerns (dendrimers) are overcome. Quantitative profiling of plasma peptides in asthmatic mice using liquid chromatography and mass spectrometry.

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A new interface for the on-line coupling of a liquid chromatograph to a stable isotope ratio mass spectrometer has been developed and tested. Gene editing tool TALENs was employed to induce downregulation expression of Nanog, and Nanog mutation was evaluated by sequencing. It utilizes a specially developed high-energy white-beam chopper whose action is synchronized with the vertical motion of the target moving at constant speed. It comprises a novel and efficient 1D multibaseline matching technique, followed by tensor voting to extract the depth surface.

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Lipid lowering drugs, such as statins, are commonly used to treat approximately 10 million Canadians affected by hypercholesterolemia. The objective of this investigation was to determine the role of Pyk2, an intracellular nonreceptor protein tyrosine kinase for postadhesive inflammatory cell migration, on airway inflammation and hyperresponsiveness in immune-sensitized mice. However, repeated Western blot analyses may be useful for the confirmation of infection or vaccination status, since the time courses of the levels of specific antibodies seem to be different. We then compare the significant motifs in highly expressed genes of the innate immune system to those in ssRNA viruses and study the evolution of these motifs in the H1N1 influenza genome.

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This TR1 form occurred in humans, dogs, and chimpanzees but was inactivated in mice and rats. Radioguided exploration (RGS) can be an important tool to direct the cytoreduction of neuroendocrine tumors (NETs). Where adequate facilities and expertise exist, colonoscopy should be the investigation of choice for most patients with large bowel symptoms suggestive of neoplastic disease. Patients with solid and liquid tumors were used to generate Kaplan-Meier estimates for survival and the probability of surviving 30, 90, and 365 days was also calculated. Pharmacological characterization of receptor redistribution and beta-arrestin recruitment assays for the cannabinoid receptor 1.

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Positive psychological characteristics, including optimism and health-related hardiness, are correlated with good self-rated health, but these variables are all affected by socioeconomic status, social support, physical illness and access to services. Generally, cell-specific extracellular enzymatic activities were inversely related to cell-specific prokaryotic leucine incorporation. Propagation of uncertainties in sample properties to the uncertainty of the counting efficiency in gamma-ray spectrometry. However, shadow region identification and segmentation is a difficult task and improperly identified shadows often interfere with machine vision tasks like object recognition and tracking.

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The properties of muscle ribonuclease I are very similar to those of bovine pancreatic ribonuclease A. THE ROLE OF MULTIPLE ARTERIOVENOUS ANASTOMOSES IN THE PATHOGENESIS OF THE DUMPING SYNDROME. However, the tolerance profile varies with the drug, which might be related to a differential selectivity of the drug for COX-1 and COX-2. Family pedigree studies of biological vulnerability to drug dependence.

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15-Deoxy-Delta12,14-prostaglandin J2 and thiazolidinediones transactivate epidermal growth factor and platelet-derived growth factor receptors in vascular smooth muscle cells. Researchers who are considering the use of graph cuts to optimize a particular energy function can use our results to determine if this is possible and then follow our construction to create the appropriate graph. Moreover, we assessed species-specific values of plant defense of these 28 species measured as the performance of a generalist caterpillar, and the preference of the caterpillar and a slug species in no-choice and choice feeding experiments, respectively.

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Using these calibration techniques to correct for process variations and dynamic changes in the sensing environment (such as temperature and magnetic field), we are able to obtain extremely sensitive and, more importantly, reproducible results for quantifiable biomolecular reorganization. We report the first case of ipilimumab monotherapy resulting in durable complete remission of untreated, progressive brain metastases in a patient with stage IV melanoma. The daily experience of the patient with an implantable cardioverter defibrillator

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ESBL producing Enterobacteriaceae isolates (based on phenotypic tests) were collected from Microbiology Laboratory of the Salmaniya Medical Complex, Bahrain between January-June 2006. This information, although rather standard in humans, is largely missing from artificial cognitive systems. The expression of Toll-like receptors in these cells is related to infection and inflammation, and tumor progression as well. The degradation of the DP structure by DNase was found to be responsible for the release of AMD and the effective killing effect of the infectious bacteria.

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Recently, a polymorphism of XBP1, a pivotal gene in the endoplasmic reticulum (ER) stress response, was shown to contribute to the genetic risk factor for bipolar disorder. An in vivo mouse model of long-term potentiation at synapses between primary afferent C-fibers and spinal dorsal horn neurons: essential role of EphB1 receptor. Mucoepidermoid carcinoma is one of the most common of the salivary gland neoplasms. Improvements in disease management should include the increased awareness of treatment-related toxicity and its prevention.

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See Guidelines for Authors for a complete description of levels of evidence. Chemical studies on tobacco-specific N-nitrosamines in the smoke of selected cigarettes from the U.S.A., West Germany, and France. Stimulus characteristics converge to influence imitation accuracy in both TD and LT toddlers and therefore should be considered when designing stimuli. The results of this study indicate that plasma DNP is increased in cirrhotic patients with ascites.

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Composite electrodes composed of silicon nanowires synthesized using the supercritical fluid-liquid-solid (SFLS) method mixed with amorphous carbon or carbon nanotubes were evaluated as Li-ion battery anodes. Triterpenoid saponins are a class of plant secondary metabolites with structure derived from the precursor oxidosqualene in which one or more sugar residues are added. High-quality cardiopulmonary resuscitation: current and future directions. Secreted LL-37 inhibited viral binding in vitro but was insufficient to protect cells completely from HSV-1 infection.

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Gold nanoparticle extraction followed by capillary electrophoresis to determine the total, free, and protein-bound aminothiols in plasma. Exploring macrocycles in functional supramolecular gels: from stimuli responsiveness to systems chemistry. Baclofen (10 microM) alone elicited no responses in ganglion cells. In spite of the liver enlargement induced by all three, in no case was total liver cholesterol significantly raised.

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The weakest link in the system is between the charged site and CE, which is remote from the initial site of excitation. Further studies are required to confirm the protein-sparing and appetite-suppressing effects of MCT supplementation during the first 2 weeks of VLCD treatment. Of the 34 p16(INK4a)-negative biopsy specimens, 26 regressed, seven persisted, and one progressed. Our results reflect a higher risk of atherosclerosis phenomena in SLE patients during flare than during clinical remission.

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Primary cerebral anaplastic large cell lymphoma (ALCL) is very rare. In summary, in BeWo cells apically internalized IgG enters both a transcytotic and recycling pathway.

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These disorders are a common cause of morbidity and mortality in psychiatric patients but physical screening by health services is often haphazard. On the basis of these results, it can be surmised that many complex attention tasks relevant to everyday life are impaired during moderate hypoglycemia. The washed platelets before and after aggregation by ADP, thrombin or collagen did not show any ability to trigger or accelerate the activation of Factor XII and prekallikrein. Differential gene expression--how to find new analgesic targets. EphrinB-EphB receptor signaling plays important roles in synaptic connection and plasticity in the nervous system, but its role in spinal synaptic plasticity remains unclear.

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CO assistance in ligand exchange of a ruthenium racemization catalyst: identification of an acyl intermediate. The process was replaced by replacement resorption leading to ankylosis and infra-occlusion of the affected tooth. Oedema with acute pseudokeratoconus corneal aspect in a case of Kearns-Sayre syndrome The effect of these beverages on the surface of both restorative materials also depended upon the exposure time and chemical composition of the restorative materials and beverages. Wharton-Jones described a coarsely granular stage in the development of granulocytic cells in animal and human blood.

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Effect of medroxyprogesterone acetate on the growth of mouse transplanted tumors: relation with hormone sensitivity. Binding site on the transferrin receptor for the parvovirus capsid and effects of altered affinity on cell uptake and infection.

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There is general consensus in the literature that childhood ML, if early and correctly diagnosed and correctly treated, has a good prognosis in most of the cases, in contrast to adult ML. A moderate lymphoplasmacytic and heterophilic perivascular dermatitis was also observed. This algorithm helps differentiate the strategy of intensive care in patients with pancreatitis, pancreatic disease, and uneventful postoperative period. The neural mechanisms responsible for strength improvement in the early phase of strength training are unknown.

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Agents which modify mono-ADP ribosylation can influence the differentiation of hemopoietic cells. We adapt a well-known model of genomic evolution to show that mortality curves producing a kink or mid-life plateaus derive from a common minimal evolutionary framework. In this paper the need for, and the potential of, leprosy and tuberculosis vaccines are discussed. Its association with leptophen permitted excellent analgesia at minimal leptophen doses, without secondary effects either during or after anaesthesia.

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Minimal residual disease (MRD) monitoring, particularly via multiparameter flow (MPF) cytometry assessed after chemotherapy, has been very useful in the prognostic and therapeutic approach for children with acute lymphoblastic leukemia. An innovative system for 3D clinical photography in the resource-limited settings. 14 hypoglossal canals were divided into two compartments by a septum. A multidimensional analysis of the impact of high-cost hospitalization. Dental device manufacturing will experience a second revolution when layered fabrication techniques reach the point of being able to produce high quality dental prostheses.

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The effective reduction of AIDS mortality could be realized through increased coverage of therapy. Gel filtration of each DEAE-Sepharose fraction on Sephadex G-200 also yielded two peaks of activity. Univariate analyses revealed differential results which included improvement in digit span and deterioration in the speed related test such as DSST and reaction time. Patients with mild hypertensive heart disease and left ventricular outflow tract obstruction: treatment with angiotensin II antagonists. By immobilizing lipid bilayers on a sensor chip surface, SPR spectroscopy has been employed to examine the binding of amyloidogenic proteins, such as amyloid beta protein (Abeta), to a variety of lipid membranes, and it provided new insights into the molecular interactions between these amyloidogenic proteins and membranes.

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Although most GPs agreed they had a role in management and felt confident to assess overweight and obesity in children, only a minority proximic bottle were putting this into practice, suggesting there are other barriers. (2006) p38 MAP kinase mediates stress-induced internalization of EGFR: implications for cancer chemotherapy. This work studies the combined experience of several orthopedic services of 267 pelvic fractures (excluding isolated iliac and sacral fractures) in childhood. Multiple forms of UDP-glucuronosyltransferase (UDPGTs) have been demonstrated in the livers of all mammalian species that have been studied.

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Intraoperative assessment of circumflex artery occlusion during mitral valve operation. Clinical pathway care improves outcomes among patients xanax alprazolam 0.25 mg hospitalized for community-acquired pneumonia. Folate nutrition is critical in humans and a high dietary folate intake is associated with a diminished risk of many types of cancer.

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Although our data support the ongoing need of cardiovascular risk factors prevention, intensified actions for primary prevention of hypertension show potential to largely reduce the burden of cardiovascular disease. Immersive audiomotor game play enhances neural and perceptual salience of weak signals in noise. In this study, we evaluated the influence imda bisque recipes of root exudates on the mobility of fuel derived compounds in contaminated soils. A stage-structured predator-prey system incorporating a class of functional responses is presented in this article.

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Caregivers are essential partners for supplying information and support during the process of change. This paper compares these different techniques proceptin reviews on windows using a multinational dataset comprising case-mix, resource use and cost data on 1300 stroke admissions from 13 centres in 11 European countries. It is concluded that women with vulval warts are no more likely than controls to have evidence of cervical epithelial abnormalities. The correlation was compared between DI and hyperspectral derivative index, and SDr has the best correlation with DI.

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MmDjC7 thus appears to be a new J-domain protein that can possibly interact with more than one Hsp70. Striae distensae in pregnancy: risk factors in primiparous women Treatment with the antithyroid drug 6-n-propyl-2-thiouracil (PTU) during the last 9 days (40 mg/kg/day) of the chronic administration of ethanol reduced hepatic oxygen consumption, resulting in a net diminution of the metabolic tolerance to ethanol, despite a further elevation in ADH activity. Comparative estimation of central haemodynamics during dynamic load by impedance cardiography and radiocardiography. Substructures at the 10-200nm scale are poorly characterized, especially lamotrigine bipolar disorder dosed in living cells, due to the limitations of electron microscopy and standard optical microscopy.

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The panel included experts in audiology, otolaryngology, communication disorders, speech language pathology, education and biomedical engineering. Sumatriptan iontophoretic transdermal system for acute treatment of episodic migraine. Whole body, spine, hip, and forearm BMC and BMD were oristal garage sale measured by dual-energy x-ray absorptiometry, and age-, sex-, and race-specific Z-scores were calculated. Human papillomavirus (HPV) is the cause of most cases of cervical cancer worldwide.

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Development of a school curriculum compliant with the NRW guideline: retrospect after 6 years implementation As the relaxation time is further increased, imigran nasal spray 10mg the viscoelastic swimming speed decreases and eventually falls below the viscous swimming speed. The aim of the Fluoxetine for Autistic Behaviors (FAB) study is to determine the efficacy and safety of low dose fluoxetine compared with placebo, for reducing the frequency and severity of repetitive stereotypic behaviors in children and adolescents with an autism spectrum disorder (ASD).

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Two concentric circles were designed with the nipple in the centre. Dentists and eating disorders--knowledge, attitudes, management levofloxacin vs ciprofloxacin in uti karolinska and experience.

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Effects noprose tabletas next tabs of gamma-interferon and tumor necrosis factor alpha on thyroid cells: induction of class II antigen and inhibition of growth stimulation. However, vectorization of tensorial data does not exploit complete structure information. An alternative route to production of bioethanol is the utilization of microorganisms that can both convert biomass to fermentable sugars and ferment the resultant sugars to ethanol in a process known as consolidated bioprocessing (CBP).

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Determination of germanium in medicinal plants by atomic absorption spectrometry with electrothermal atomization. Stability of dye doped cholesteric liquid crystal laser emission from several minutes up to two hours and more was achieved by rotating the side effects to starting zoloft liquid crystal cell.